Jurnal ini diterbitkan secara berkala dua kali dalam setahun, pada bulan Juli dan Desember. Jurnal Farmasi dan Farmakoinformatika (JFF) merupakan jurnal yang memuat artikel ilmiah dalam skop farmasi (seperti Farmasi Klinis dan Komunitas, Farmakologi, Teknologi Farmasi, Kimia Farmasi, Farmasi Bahan Alam, Manajemen Farmasi) dan teknologi informatika dibidang farmasi (seperti Farmakoinformatika, serta Bioinformatika dan Genetika) yang ditulis dalam bahasa Indonesia maupun bahasa Inggris. Jurnal ini diterbitkan oleh Bagian Publikasi Universitas Gunadarma. This journal is published periodically twice a year, in July and December by Publication Section of Gunadarma University. Journal of Pharmacy and Pharmacoinformatics (JFF) is a journal that contains scientific articles in the scope of pharmacy (such as Clinical and Community Pharmacy, Pharmacology, Pharmaceutical Technology, Pharmaceutical Chemistry, Natural Pharmacy, Pharmaceutical Management) and information technology in the pharmaceutical (such as Pharmacoinformatics, and Bioinformatics and Genetics). The submitted articles can be written in Bahasa Indonesia or English.
Evaluasi Penggunaan Antibiotik Pada Pasien Infeksi Saluran Pernapasan Akut Atas (ISPAa) Di Instalasi Rawat Jalan Rumah Sakit X
Acute Upper Respiratory Tract Infection (AURTI) is a disease caused by an acute infection affecting the upper respiratory tract, typically resulting from bacteria and viruses. According to the 2018 Riskesdas report from the DKI Jakarta province, AURTI is among the most common infectious diseases in Jakarta, with a prevalence of 8.49%. The data indicates that AURTI is a recurring health issue each year, with several factors contributing to the rising incidence, one of which is irrational treatment. This study aims to determine the pattern of antibiotic use and the rationality of antibiotic use in AURTI therapy. This research is a non-experimental study with retrospective data collection and descriptive data analysis. The results show that the most commonly used antibiotics were cefixime (67%), azithromycin (14%), amoxicillin-clavulanate (8%), clindamycin (6%), amoxicillin (4%), and levofloxacin (2%), with oral administration. Of the 51 AURTI patient records evaluated in the Outpatient Department, the results showed 100% appropriateness in patient selection, 100% appropriateness in indication, 39% appropriateness in drug selection, 100% appropriateness in dosage, 96% appropriateness in duration, 94% appropriateness in frequency and route of administration 100%.
Acute Upper Respiratory Tract Infection (ISPAA)
Hak Cipta (c) 2026 Jurnal Farmasi dan Farmakoinformatika https://creativecommons.org/licenses/by/4.0
Pemetaan Lanskap Ilmiah Penelitian Obat Herbal Indonesia (1983–2026): Analisis Bibliometrik
Herbal medicine research in Indonesia has experienced rapid development along with the increasing interest in natural-based treatments and the utilization of biodiversity. This study aims to map the scientific landscape of herbal medicine research in Indonesia during the period 1983–2026 using a bibliometric approach. Data were obtained from the Scopus database with keywords related to herbal medicine, traditional medicine, phytotherapy, and ethnopharmacology combined with the Indonesian context. Analysis was conducted using VOSviewer and Biblioshiny software to evaluate publication trends, journal sources, author productivity, institutional affiliations, citations, and keyword mapping. The results show 659 publications from 333 sources, with an annual growth rate of 6.5%. The publication trend has increased significantly since 2016 and peaked in 2025 with 92 articles. Keyword analysis shows the dominance of topics such as herbal medicine, plant extract, phytochemistry, and antioxidant activity, indicating that the research focus is still at the pre-clinical stage. Publication sources are dominated by proceedings such as the IOP Conference Series (35 articles) and journals such as Biodiversitas (32 articles). The most productive institutions were Airlangga University (95 publications) and Gadjah Mada University (82 publications), with an average of 4.9 authors per article and 17.91% international collaboration. The highest-impact articles received 313 citations, demonstrating the importance of publication in reputable journals. In conclusion, herbal medicine research in Indonesia has shown significant growth but is still dominated by exploratory research. Improvements in publication quality, international collaboration, and strengthening translational research are needed to support the development of evidence-based herbal medicines and enhance Indonesia's contribution globally.
Efek Antiinflamasi Jus Bawang Putih terhadap Kadar C-Reactive Protein (CRP) pada Tikus Jantan Galur Sprague Dawley yang Diinduksi Karagenan
Garlic (Allium sativum L.) is known to contain bioactive compounds with pharmacological potential, including anti-inflammatory activity. Inflammation is characterized by an increase in the biomarker C-reactive protein (CRP), which is produced by the liver in response to inflammatory processes. This study aimed to evaluate the anti-inflammatory effect of garlic juice on CRP levels in male Sprague Dawley rats induced with carrageenan. An experimental design was applied using 24 male rats divided into six groups: normal control, negative control (Na-CMC 1%), positive control (diclofenac sodium 4.5 mg/kgBW), and treatment groups receiving garlic juice at doses of 300, 400, and 500 mg/kgBW. Inflammation was induced by 1% carrageenan injection, and CRP levels were measured using the CRP-latex method. The results showed that garlic juice significantly reduced CRP levels compared with the negative control (p<0.05). The 500 mg/kgBW dose produced the most optimal effect, approaching the efficacy of the positive control. Therefore, garlic juice has potential as a natural anti-inflammatory agent effective in reducing CRP levels.
Studi Etnofarmasi dan Identifikasi Faktor-Faktor yang Mempengaruhi Penggunaan Tumbuhan Obat sebagai Terapi Hipertensi pada Masyarakat Desa Poka, Kecamatan Teluk Ambon, Kota Ambon, Provinsi Maluku
Ethnopharmacy is an approach used to explore the traditional use of medicinal plants within communities, which holds potential for the development of modern medicines. Hypertension is one of the non-communicable diseases that continues to pose a global health threat and requires proper management. This study aims to identify the types of plants used by the community for hypertension therapy, their processing methods, and the factors influencing their use. The method applied was observational with a cross-sectional design, conducted through questionnaires and interviews. Plant samples mentioned by the community were collected as herbarium specimens and analyzed for their chemical compound groups. The research conducted in Poka Village revealed 10 types of plants used for managing hypertension, including cat’s whiskers, Phyllanthus niruri, moringa, African leaf, basil, celery, lemongrass, pandan, soursop, and gotu kola. The three most commonly used plants were cat’s whiskers (17.5%), Phyllanthus niruri (15%), and moringa (15%). Information regarding their use was primarily obtained from family traditions (40%). Usage was irregular and typically applied only when necessary, with the most common preparation method being boiling (51%). The main factors influencing the use of herbal therapy included: natural ingredients (22.5%), easy availability (20%), family traditions (15%), fewer side effects (12.5%), and beliefs in their effectiveness and affordability. These findings highlight the need for government-led education and outreach to ensure the safe and optimal use of herbal medicine.
Hak Cipta (c) 2025 Jurnal Farmasi dan Farmakoinformatika https://creativecommons.org/licenses/by/4.0
Optimasi Formula Serum Wajah Menggunakan Ekstrak Etanol Daun Kelor (Moringa oleifera L.) sebagai Pelembap Kulit
Moringa (Moringa oleifera L.) is a member of the Moringaceae family that is rich in flavonoids and phenolics, especially in the leaves, with potential as an antioxidant and skin moisturizer. Serum is a preparation made with low viscosity so that it can deliver a thin film of active substances to the skin surface and has a high water content so that it can hydrate the skin. This study aims to optimize the formula of a face serum based on ethanol extract of moringa leaves. The extract was obtained using the maceration method and tested at concentrations of 2%, 4%, and 6%. The highest antioxidant activity was shown at a concentration of 6%, which was used as the optimal concentration in formulations with variations of 5%, 10%, and 15% glycerin. Antioxidant activity was tested in vitro using the DPPH method with UV-Vis spectrophotometry, while skin moisture was tested using a moisture skin analyzer. The results showed that all formulations met physical quality standards and had moderate to strong antioxidant activity with IC₅₀ values of F0 (36,772 ppm), F1 (26,966 ppm), F2 (25,300 ppm), and F3 (23,591 ppm). Increased concentrations of extract and glycerin were associated with decreased IC₅₀ values and increased moisturizing effects, with formula 4 producing the most optimal performance.
Ethanol Extract of Moringa oleifera L. Leaves
Formulasi dan Uji Stabilitas Krim Tabir Surya Mengandung Titanium Dioksida (TiO2) dengan Variasi Emulgator
The use of sunscreen creams can protect the function of human skin structures from the negative effects of UV rays. This study aims to formulate sunscreen cream preparations with variations of polysorbate and sorbitan emulgators to determine the physical characteristics of cream preparations and determine the stability of sunscreen cream preparations containing titanium dioxide (TiO2) to SPF (Sun Protection Factor) values. This research uses laboratory experimental methods. The active ingredient used is TiO2, which is a physical blocker by reflecting UV radiation. Polysorbate and sorbitan are the emulgator combinations used in this study. Sunscreen cream preparations were formulated into four formulas by combining and varying the concentration of polysorbate and sorbitan emulgators. FI contained polysorbate 60 (3%) and sorbitan 60 (2%), FII polysorbate 80 (2.5%) and sorbitan 80 (2.5%), FIII polysorbate 60 (2.75%) and sorbitan 80 (2.25%), and FIV polysorbate 80 (3.25%) and sorbitan 60 (1.75%). Furthermore, the preparations were evaluated and tested for stability (cycling test,) as well as effectiveness determination tests (SPF, and %TE). The results showed that different combinations and variations in the concentration of polysorbate and sorbitan emulgators in the four formulas had an influence on the physical characteristics and stability of the preparation. And the results of the determination of the effectiveness of sunscreen cream have an influence of UV exposure on the in vitro effectiveness of sunscreen cream (SPF, and %TE).
Pengaruh Variasi Konsentrasi Asam Stearat Terhadap Stabilitas Fisik Sediaan Krim Tabir Surya Ekstrak Daun Sirih Hijau (Piper betle L.)
Exposure to ultraviolet rays at a certain level cannot be accepted by human skin. Objective: This study aims to see the potential value of the Sun Protection Factor (SPF) of green betel leaves (Piper betle L.) by finding good stability using stearic acid. Methods: This study was conducted with a qualitative approach with a laboratory experimental method. Data collection directly from the laboratory to determine whether there is sunscreen activity in green betel leaf extract (Piper betle L.) to see if there is a difference in the effect of stearic acid concentration on the stability of green betel leaf extract sunscreen cream (Piper betle L.). Results: The results obtained are that green betel leaf extract (Piper betle L.) has sunscreen activity with the higher the concentration of the extract, the higher the Sun Protection Factor (SPF) value. This can be proven by the results of data processing obtained, every 1% increase in concentration value. Then the SPF value increases by 0.21. The results of the stability test showed stable results with organoleptic consistency, pH, and homogeneity, and spreadability. After being formulated, the sunscreen cream has a Sun Protection Factor (SPF) value, the higher the concentration of stearic acid, the lower the SPF value, this can be proven by the results of data processing with the addition of 1% concentration value. Conclusion: The Sun Protection Factor (SPF) value decreases by -0.900 but the stability of the preparation shows good results. This study suggests that it is necessary to test the antioxidant levels in green betel leaf extract (Piper betle L.).
Analisis Potensi Kejadian Medication Errors pada Fase Prescribing dalam Pelayanan Resep Pasien Rawat Jalan di Rumah Sakit Bhayangkara Brimob
Prescription assessment is an activity that plays an important role in ensuring appropriate drug use and preventing medication errors. Medication errors most often occur in the prescribing phases, which is medication errors that occur during drug prescribing. This study aims to determine the implementation of prescription assessment and the potential incidence of medication errors in the prescribing phase in the assessment of outpatient prescriptions at Hospital Bhayangkara Brimob. The type of research used in this study is non-experimental research using descriptive research methods with retrospective data collection for the period October – December 2023. Sampling was the techniques of purposive sampling and calculated using the slovin formula so as to get minimum sample of 395 prescriptions and the number of samples used in this study was 450 prescriptions. The results showed that there was a potential for medication errors in the prescribing phase based on pharmaceutical and clinical requirements. In pharmaceutical requirements, it was found that the name, form or dosage strength of the drug was no listed by 14% (63 prescriptions), inapproopriate drug dosage by 25,33% (114 prescriptions), and inappropriate use rules by 20% (90 prescriptions). In clinical requirements, duplication of drugs was found at 1,11% (5 prescriptions) and drug interactions at 20,22% (91 prescriptions). Meanwhile, administrative requirements did not identify any potential medication errors. The conclusion of this study is that outpatient prescriptions at Bhayangkara Brimob Hospital still have the potential for medication errors in the prescribing phase based on pharmaceutical and clinical requirements.
Analisis Kadar Octyl Methoxycinnamate (OMC) Dalam Sediaan Gel Tabir Surya dengan Metode Spektrofotometri UV-Vis
Indonesia is one of the countries with a tropical climate with temperatures around 18-38°C. Indonesia is experiencing an increase in temperature so it is recommended to use sunscreen. One of the ingredients in sunscreen preparations is an octyl methoxycinnamate compound that can protect the skin from UVB rays. Badan Pengawas Obat dan Makanan (BPOM) stipulates that the maximum concentration of octyl methoxycinnamate allowed in sunscreen cosmetic preparations is 10%. The purpose of this study was to determine the levels of octyl methoxycinnamate contained in sunscreen gel samples circulating in Cibinong Market by UV-Vis spectrophotometric method. This study used the UV-Vis spectrophotometric method that has been validated for the analysis of octyl methoxycinnamate levels in sunscreen gel preparations. Based on the optimization results, it was found that the optimal solvent to attract OMC was isopropanol as shown by the linear equation y = 0.1003x + 0.0111 (R2 = 0.9998). Validation of the analytical method includes specificity showing OMC standard at λmax 308.5 nm; linearity with concentrations of 2, 3, 4, 5, 6, and 7 μg/mL with a value of y = 0.1006x+0.0102 (R2 = 0.9999); accuracy is shown from the percent of recovery is 127.88%; 113.67%; 108.44%; precision is also shown with %RSD with measurements are 0.4283%; 0.1255%; 0.122%, respectively; BD value = 0.679 μg/mL, and BK value = 2.058 μg/mL. This study using three sunscreen gel samples obtained from shops in Cibinong market showed that all gel samples containing octyl methoxycinnamate did not exceed the specified concentration, where sample A was 2.81%; sample B was 0.96%; and sample C was 0.37%.
Uji Angka Kapang Khamir (AKK) dan Angka Lempeng Total (ALT) pada Jamu Kunyit Asam Kemasan Serbuk
A famous traditional herbal cure created from natural materials, turmeric and tamarind herbal medicine (jamu turmeric tamarind) is now readily available in powder form. The purpose of this study is to evaluate the safety and quality of powdered turmeric and tamarind herbal medicine by looking at factors including water content, total phenolic content, and microbiological contamination. Six brands of commercially available powdered turmeric and tamarind herbal medicine were the subject of an experimental laboratory investigation. The Folin–Ciocalteu method was used to determine the total phenolic content, the gravimetric technique was used to measure the water content, and the pour plate method was used to conduct the Yeast Mold Count (YMC) and Total Plate Count (TPC) assays. The findings indicated that all samples had AKK values ​​between <1 and 1.7 × 10¹ cfu/g and ALT values ​​between <1 and 1.2 × 10⁴ cfu/g, both of which were below the upper limit established by BPOM Regulation Number 29 of 2023. Significant variations were observed in the total phenolic levels among the samples; the maximum value was 121.03 mg GAE/g, while other samples had extremely low values. All of the samples met the quality requirements for natural medical powder formulations since their water contents ranged from 0.62 to 7.20%, which is less than 10%. The analyzed powdered turmeric and tamarind herbal medicine satisfies microbiological safety and quality criteria, has an acceptable water content, and exhibits a range of bioactive potential, according to these findings.
Analisis Pengaruh Faktor Sosial Ekonomi terhadap Kepatuhan Pasien dalam Penggunaan Antibiotika Secara Oral di Puskesmas X Kota Depok
The inappropriate use of antibiotics is one of the main factors contributing to antimicrobial resistance (AMR), which significantly increases global morbidity and mortality rates. Patient adherence to antibiotic regimens plays a crucial role in preventing the development of resistance. Socioeconomic factors, such as educational level, occupation, and income, are suspected to influence adherence levels. This study aims to analyze the impact of socioeconomic factors on adherence to oral antibiotic use at Puskesmas X in Depok City. The results indicate that socioeconomic factors (education, occupation, and income) collectively have a significant effect on adherence to oral antibiotic use, contributing 10.8% to the variance in adherence, while the remaining 89.2% is influenced by other unexamined factors. An ANOVA (F-test) yielded a significance value of 0.011 (< 0.05), thereby supporting the general hypothesis (H1). Further analysis using partial t-tests revealed that educational level was the most influential factor, with a significance value of 0.052, close to the α threshold of 0.05. This finding suggests that higher educational attainment enhances individuals’ ability to understand medical information and follow antibiotic usage instructions, thereby improving adherence. Conversely, occupation (α = 0.759) and income level (α = 0.122) did not demonstrate a significant influence on adherence to oral antibiotic use
Validasi Metode Spektrofotometri UV-Vis untuk Analisis Octyl Methoxycinnamate (OMC) pada Sampel Powder Tabir Surya.
Indonesia has a high intensity of sun exposure (Ultraviolet). To protect the skin from these UV rays, it is recommended to use cosmetics that contain special compounds as sunscreens, namely octyl methoxycinnamate (OMC). BPOM recommends the maximum concentration of OMC in sunscreen cosmetics is 10%. This study aims to validate the method of analysing OMC levels using UV-Vis spectrophotometer in loose powder sunscreen preparations that have been circulating. The validation method includes specificity, linearity, accuracy, precision, BD and BK. The optimal solvent was isopropanol, showing a linear regression equation y = 0.1003x + 0.0111; R² = 0.9998. Validation of the analytical method: λmax specificity of OMC standard 308.5 nm; linearity y = 0.1006x + 0.0102; R² = 0.9999. The % recovery values with concentrations of 80%, 100% and 120%, namely 122.18%; 113.88%; 106.66%. The % RSD values were 0.68%; 0.15%; 0.18%. BD value = 0.68 µg/mL; and BK = 2.06 µg/mL. The loose powder sunscreen sample A was 1.42% (b/v). Sample B was 0.22% (b/v) and sample C was 1.69% (b/v). OMC in sunscreen cosmetics fulfils the requirements recommended by BPOM.